Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study.

ABSTRACT:

Background

Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary methionine and cysteine restriction on cardiometabolic risk factors, plasma and urinary amino acid profile, serum fibroblast growth factor 21 (FGF21), and subcutaneous adipose tissue gene expression in women with overweight and obesity in a double-blind randomized controlled pilot study.

Methods

Twenty women with overweight or obesity were allocated to a diet low (Met/Cys_-low, n = 7), medium (Met/Cys_-medium, n = 7) or high (Met/Cys_-high, n = 6) in methionine and cysteine for 7 days. The diets differed only by methionine and cyste

SUBMITTER: Olsen T 

PROVIDER: S-EPMC7065370 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature