Immunological risk stratification and tailored minimisation of immunosuppression in renal transplant recipients.

ABSTRACT:

Background

The efficacy and safety of minimisation of immunosuppression including early steroid withdrawal in kidney transplant recipients treated with Basiliximab induction remains unclear.

Methods

This retrospective cohort study reports the outcomes from 298 consecutive renal transplants performed since 1st July 2010-June 2013 treated with Basiliximab induction and early steroid withdrawal in low immunological risk patients using a simple immunological risk stratification and 3-month protocol biopsy to optimise therapy. The cohort comprised 225 low-risk patients (first transplant or HLA antibody calculated reaction frequency (CRF ≤50% with no donor specific HLA antibodies) who underwent basiliximab induction, steroid withdrawal on day 7 and maintenance with tacrolimus and

SUBMITTER: Phanish MK 

PROVIDER: S-EPMC7065371 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature