Comparative expression profiles of host circulating miRNAs in response to Trichinella spiralis infection.

ABSTRACT: Trichinellosis is an important food-borne parasitic zoonosis throughout the world. At present, the mechanisms of Trichinella spiralis infection remain unclear. Acquiring detailed information on the host-Trichinella interaction would be beneficial for the development of new strategies for trichinellosis control. Circulating miRNAs are stably detectable in the blood of humans and animals infected with parasites. Circulating miRNAs might regulate the expression of target genes in pathological responses during infection and might be novel potential biomarkers of parasitic diseases. In the present study, a total of ten differentially expressed circulating mouse miRNAs with |log₂(fold change)| ≥ 1.0 and FDR < 0.01 were found during T. spiralis infection, of which five were upregulated

SUBMITTER: Ma XH 

PROVIDER: S-EPMC7065375 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature