Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus, Rhodocodon rotundus and Rhodocodon cyathiformis.

ABSTRACT:

Background

Homoisoflavonoids have been shown to have potent anti-proliferative activities in endothelial cells over other cell types and have demonstrated a strong antiangiogenic potential in vitro and in vivo in animal models of ocular neovascularization. Three species of Rhodocodon (Scilloideaea subfamily of the Asparagaceae family), endemic to Madagascar, R. cryptopodus, R. rotundus and R. cyathiformis, were investigated.

Purpose

To isolate and test homoisoflavonoids for their antiangiogenic activity against human retinal microvascular endothelial cells (HRECs), as well as specificity against other ocular cell lines.

Methods

Plant material was extracted at room temperature with EtOH. Compounds were isolated using flash column chromatography and were identified usin

SUBMITTER: Whitmore H 

PROVIDER: S-EPMC7065379 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature