Spectral correction for handheld optoacoustic imaging by means of near-infrared optical tomography in reflection mode.

ABSTRACT: In vivo imaging of tissue/vasculature oxygen saturation levels is of prime interest in many clinical applications. To this end, the feasibility of combining two distinct and complementary imaging modalities is investigated: optoacoustics (OA) and near-infrared optical tomography (NIROT), both operating noninvasively in reflection mode. Experiments were conducted on two optically heterogeneous phantoms mimicking tissue before and after the occurrence of a perturbation. OA imaging was used to resolve submillimetric vessel-like optical absorbers at depths up to 25 mm, but with a spectral distortion in the OA signals. NIROT measurements were utilized to image perturbations in the background and to estimate the light fluence inside the phantoms at the wavelength pair (760 nm, 830 nm). This enab

SUBMITTER: Ulrich L 

PROVIDER: S-EPMC7065640 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature