Alternative splice variants of rhomboid proteins: Comparative analysis of database entries for select model organisms and validation of functional potential.

ABSTRACT: Background: Rhomboid serine proteases are present across many species and are often encoded in each species by more than one predicted gene. Based on protein sequence comparisons, rhomboids can be differentiated into groups - secretases, presenilin-like associated rhomboid-like (PARL) proteases, iRhoms, and "inactive" rhomboid proteins. Although these rhomboid groups are distinct, the different types can operate simultaneously. Studies in Arabidopsis showed that the number of rhomboid proteins working simultaneously can be further diversified by alternative splicing. This phenomenon was confirmed for the Arabidopsis plastid rhomboid proteins At1g25290 and At1g74130. Although alternative splicing was determined to be a significant mechanism for diversifying these two

SUBMITTER: Powles J 

PROVIDER: S-EPMC7065720 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature