Estimated number of adult survivors of childhood cancer in United States with cancer-predisposing germline variants.

ABSTRACT:

Purpose

To estimate the absolute number of adult survivors of childhood cancer in the U.S. population who carry a pathogenic or likely pathogenic variant in a cancer predisposition gene.

Methods

Using the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated the number of childhood cancer survivors on December 31, 2016 for each childhood cancer diagnosis, multiplied this by the proportion of carriers of pathogenic/likely pathogenic variants in the St. Jude Lifetime Cohort (SJLIFE) study, and projected the resulting number onto the U.S.

Population

Results

Based on genome sequence data, 11.8% of 2450 SJLIFE participants carry a pathogenic/likely pathogenic variant in one of 156 cancer predisposition genes. Given this information, we estimate t

SUBMITTER: Wilson CL 

PROVIDER: S-EPMC7065721 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature