Soluble Urokinase Receptor and Acute Kidney Injury.

ABSTRACT:

Background

Acute kidney injury is common, with a major effect on morbidity and health care utilization. Soluble urokinase plasminogen activator receptor (suPAR) is a signaling glycoprotein thought to be involved in the pathogenesis of kidney disease. We investigated whether a high level of suPAR predisposed patients to acute kidney injury in multiple clinical contexts, and we used experimental models to identify mechanisms by which suPAR acts and to assess it as a therapeutic target.

Methods

We measured plasma levels of suPAR preprocedurally in patients who underwent coronary angiography and patients who underwent cardiac surgery and at the time of admission to the intensive care unit in critically ill patients. We assessed the risk of acute kidney injury at 7 days as the pr

SUBMITTER: Hayek SS 

PROVIDER: S-EPMC7065830 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature