Adjusting for age improves identification of gut microbiome alterations in multiple diseases.

ABSTRACT: Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-microbiome associations display specific age-centric trends. Ageing-associated microbiome alterations towards a disease-like configuration occur in colorectal cancer patients, thereby masking disease signatures. We identified a microbiome disease response shared across multiple diseases in elderly subjects that is distinct from that in young/middle-aged individuals, but also a novel set of taxa consistently gained in disease across all age groups. A subset of these taxa was as

SUBMITTER: Ghosh TS 

PROVIDER: S-EPMC7065848 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature