Intrinsic neural circuitry of depression in adolescent females.

ABSTRACT:

Background

Adolescence is characterized by affective and cognitive changes that increase vulnerability to depression, especially in females. Neurodevelopmental models attribute adolescent depression to abnormal responses in amygdala, striatum, and prefrontal cortex (PFC). We examined whether the strength of functional brain networks involving these regions predicts depression symptoms in adolescent females.

Methods

In this longitudinal study, we recorded resting-state functional connectivity (RSFC) in 174 adolescent females. Using a cross-validation strategy, we related RSFC profiles that included (a) a network consisting of amygdala, striatum, and PFC (within-circuit model), (b) connectivity of this network to the whole brain (extended-circuit model), and (c) a network cons

SUBMITTER: Jin J 

PROVIDER: S-EPMC7065934 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature