Strategies for targeting the cardiac sarcomere: avenues for novel drug discovery.

ABSTRACT: Introduction: Heart failure remains one of the largest clinical challenges in the United States. Researchers have continually searched for more effective heart failure treatments that target the cardiac sarcomere but have found few successes despite numerous expensive cardiovascular clinical trials. Among many reasons, the high failure rate of cardiovascular clinical trials may be partly due to incomplete characterization of a drug candidate's complex interaction with cardiac physiology.Areas covered: In this review, the authors address the issue of preclinical cardiovascular studies of sarcomere-targeting heart failure therapies. The authors consider inherent tradeoffs made between mechanistic transparency and physiological fidelity for several relevant preclinical technique

SUBMITTER: Holmes JB 

PROVIDER: S-EPMC7065952 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature