Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using OCT Angiography.

ABSTRACT:

Purpose

To study longitudinal changes in retinal capillary circulation in eyes treated with iodine 125 (I¹²⁵) plaque brachytherapy for uveal melanoma using OCT angiography (OCTA).

Design

Longitudinal prospective study of 21 patients undergoing treatment for uveal melanoma with I¹²⁵ plaque brachytherapy. Eyes with melanoma were imaged with OCTA before treatment and at 12-month intervals until 2 years after brachytherapy.

Participants

After institutional review board approval, participants were enrolled prospectively from an academic ocular oncology clinic.

Methods

Peripapillary (4.5 × 4.5-mm) and macular (3 × 3-mm) OCTA scans were acquired with AngioVue (Optovue, Inc, Fremont, CA).

Main outcome measures

The peripapillary nerve fiber

SUBMITTER: Skalet AH 

PROVIDER: S-EPMC7065970 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature