Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets.

ABSTRACT: The shapes of particles and their distribution in tablets, controlled by pretreatment and tableting process, determine the pharmaceutical performance of excipient like lubricant. This study aims to provide deeper insights to the relationship of the morphology and spatial distribution of stearic acid (SA) with the lubrication efficiency, as well as the resulting tablet property. Unmodified SA particles as flat sheet-like particles were firstly reprocessed by emulsification in hot water to obtain the reprocessed SA particles with spherical morphology. The three-dimensional (3D) information of SA particles in tablets was detected by a quantitative and non-invasive 3D structure elucidation technique, namely, synchrotron radiation X-ray micro-computed tomography (SR-µCT). SA particles in glipiz

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7066036 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature