Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry.

ABSTRACT: We describe a new technique, high fidelity Imaging Retinal Densitometry (IRD), which probes the functional integrity of the outer retinal complex. We demonstrate the ability of the technique to map visual pigment optical density and synthesis rates in eyes with and without macular disease. A multispectral retinal imaging device obtained precise measurements of retinal reflectance over space and time. Data obtained from healthy controls and 5 patients with intermediate AMD, before and after photopigment bleaching, were used to quantify visual pigment metrics. Heat maps were plotted to summarise the topography of rod and cone pigment kinetics and descriptive statistics conducted to highlight differences between those with and without AMD. Rod and cone visual pigment synthesis rates in those

SUBMITTER: Margrain TH 

PROVIDER: S-EPMC7066170 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature