Ontology highlight
ABSTRACT:
SUBMITTER: Calandrini C
PROVIDER: S-EPMC7066173 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Calandrini Camilla C Schutgens Frans F Oka Rurika R Margaritis Thanasis T Candelli Tito T Mathijsen Luka L Ammerlaan Carola C van Ineveld Ravian L RL Derakhshan Sepide S de Haan Sanne S Dolman Emmy E Lijnzaad Philip P Custers Lars L Begthel Harry H Kerstens Hindrik H D HHD Visser Lindy L LL Rookmaaker Maarten M Verhaar Marianne M Tytgat Godelieve A M GAM Kemmeren Patrick P de Krijger Ronald R RR Al-Saadi Reem R Pritchard-Jones Kathy K Kool Marcel M Rios Anne C AC van den Heuvel-Eibrink Marry M MM Molenaar Jan J JJ van Boxtel Ruben R Holstege Frank C P FCP Clevers Hans H Drost Jarno J
Nature communications 20200311 1
Kidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. It contains tumour and matching normal kidney organoids from over 50 children with different subtypes of kidney cancer, including Wilms tumours, malignant rhabdoid tumours, rena ...[more]