Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.

ABSTRACT:

Background

The BLUE 400 filter system (Carl Zeiss Meditec, Oberkochen, Germany) has provided visualization of 5-ALA-induced fluorescence-guided surgery for more than 20 years. Nevertheless, constraints, e.g., limited background discrimination during hemostasis, obstruct fluency of surgery. A novel filter with improved background visualization was developed, requiring validation regarding fluorescence discrimination. The aim of this article is to determine diagnostic accuracy and perception of protoporphyrin IX (PpIX) discrimination of a novel filter system with higher background illumination (BLUE 400 AR) compared with the gold standard, BLUE 400.

Methods

A surgical microscope equipped with both BLUE 400 and BLUE 400 AR was used. Comparisons were performed on a biological ba

SUBMITTER: Suero Molina E 

PROVIDER: S-EPMC7066295 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature