Delineation of Homeostatic Immune Signatures Defining Viremic Non-progression in HIV-1 Infection.

ABSTRACT: Viremic non-progressors (VNPs), a distinct group of HIV-1-infected individuals, exhibit no signs of disease progression and maintain persistently elevated CD4+ T cell counts for several years despite high viral replication. Comprehensive characterization of homeostatic cellular immune signatures in VNPs can provide unique insights into mechanisms responsible for coping with viral pathogenesis as well as identifying strategies for immune restoration under clinically relevant settings such as antiretroviral therapy (ART) failure. We report a novel homeostatic signature in VNPs, the preservation of the central memory CD4+ T cell (CD4+ T _CM ) compartment. In addition, CD4+ T_CM preservation was supported by ongoing interleukin-7 (IL-7)-mediated thymic repopulation o

SUBMITTER: Singh AK 

PROVIDER: S-EPMC7066316 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature