Identification and genome analysis of a novel 17β-estradiol degradation bacterium, Lysinibacillus sphaericus DH-B01.

ABSTRACT: The natural estrogen 17β-estradiol (17β-E2) is a major endocrine disruptor. Accordingly, due to their frequent presence in global surface waters, prolonged exposure to estrogen-contaminated water may disrupt sexual development in animals. It has adverse effects on wildlife and humans. To date, the most effective strategy for estrogen removal from the environment is biodegradation using microorganisms. To this end, we isolated a strain of Lysinibacillus sphaericus, namely DH-B01, from a contraceptive factory in Beijing. The experimental results revealed that the bacterium has a high capacity to degrade estrogen, with a 17β-E2 degradation rate of about 97%, and produces the secondary metabolite estrone. In addition, a series of genes involved in steroid metabolism and stress response

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7066359 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature