Deciphering N⁶-Methyladenosine-Related Genes Signature to Predict Survival in Lung Adenocarcinoma.

ABSTRACT: Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death. Among these, lung adenocarcinoma (LUAD) accounts for most cases. Due to the improvement of precision medicine based on molecular characterization, the treatment of LUAD underwent significant changes. With these changes, the prognosis of LUAD becomes diverse. N⁶-methyladenosine (m⁶A) is the most predominant modification in mRNAs, which has been a research hotspot in the field of oncology. Nevertheless, little has been studied to reveal the correlations between the m⁶A-related genes and prognosis in LUAD. Thus, we conducted a comprehensive analysis of m⁶A-related gene expressions in LUAD patients based on The Cancer Genome Atlas (TCGA) database by revea

SUBMITTER: Zhu J 

PROVIDER: S-EPMC7066421 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature