Bifidobacterium longum-fermented rice bran and rice bran supplementation affects the gut microbiome and metabolome.

ABSTRACT: This study investigated gut microbiota composition along with food, host, and microbial derived metabolites in the colon and systemic circulation of healthy mice following dietary rice bran and fermented rice bran intake. Adult male BALB/c mice were fed a control diet or one of two experimental diets containing 10% w/w rice bran fermented by Bifidobacterium longum or 10% w/w non-fermented rice bran for 15 weeks. Metabolomics was performed on the study diets (food), the murine colon and whole blood. These were analysed in concert with 16S rRNA amplicon sequencing of faeces, caecum, and colon microbiomes. Principal components analysis of murine microbiota composition displayed marked separation between control and experimental diets, and between faecal and tissue (caecum and colon) mi

SUBMITTER: Nealon NJ 

PROVIDER: S-EPMC7066528 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature