M⁶A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer.

ABSTRACT:

Background

The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m⁶A) modification in tumor microenvironment (TME) cell infiltration remain unknown.

Methods

We comprehensively evaluated the m⁶A modification patterns of 1938 gastric cancer samples based on 21 m⁶A regulators, and systematically correlated these modification patterns with TME cell-infiltrating characteristics. The m6Ascore was constructed to quantify m⁶A modification patterns of individual tumors using principal component analysis algorithms.

Results

Three distinct m⁶A modification patterns were determined. The TME cell-infiltrating characteristics under these thr

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7066851 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature