Increased neural sensitivity to self-relevant stimuli in major depressive disorder.

ABSTRACT: The current research examined how individuals with depression process emotional, self-relevant stimuli. Across two studies, individuals with depression and healthy controls read stimuli that varied in self-relevance while EEG data were recorded. We examined the late positive potential (LPP), an ERP component that captures the dynamic allocation of attention to motivationally salient stimuli. In Study 1, participants read single words in a passive-viewing task. Participants viewed negative, positive, or neutral words that were either normative or self-generated. Exploratory analyses indicated that participants with depression exhibited affective modulation of the LPP for self-generated stimuli only (both positive and negative) and not for normative stimuli; healthy controls exhibited simila

SUBMITTER: Benau EM 

PROVIDER: S-EPMC7066870 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature