Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.

ABSTRACT: Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy¹. Clinically, it is challenging to differentiate Parkinson's disease and multiple system atrophy, especially at the early stages of disease². Aggregates of α-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of α-synuclein that can self-propagate and spread from cell to cell^3-6. Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect α-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity^7,8. Here we show t

SUBMITTER: Shahnawaz M 

PROVIDER: S-EPMC7066875 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature