Establishment and characterization of patient-derived xenografts for hormone-naive and castrate-resistant prostate cancers to improve treatment modality evaluation.

ABSTRACT: Prostate cancer (PC) is a heterogeneous disease characterized by variable morphological patterns. Thus, establishing a patient-derived xenograft (PDX) model that retains the key features of the primary tumor for each type of PC is important for appropriate evaluation. In this study, we established PDX models of hormone-naïve (D17225) and castration-resistant (B45354) PC by implanting fresh tumor samples, obtained from patients with advanced PC under the renal capsule of immune-compromised mice. Supplementation with exogenous androgens shortened the latent period of tumorigenesis and increased the tumor formation rate. The PDX models exhibited the same major genomic and phenotypic features of the disease in humans and maintained the main pathological features of the primary tumors. Moreover

SUBMITTER: Wu P 

PROVIDER: S-EPMC7066917 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature