Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis.

ABSTRACT: Exosomes are reported to mediate several disease-related microRNAs (miRNAs) to affect the progression of diseases, including atherosclerosis. Here, we aimed to screen the atherosclerosis-associated miRNAs and preliminarily investigate the potential regulatory mechanism of atherosclerosis. First, the lesion model for human umbilical vein endothelial cells (HUVECs) was favorably constructed. Later, through RNA-sequencing and bioinformatics analyses, miR-342-5p was identified in lesion model for HUVECs. MiR-342-5p overexpression or knockdown evidently promoted or inhibited the apoptosis of HUVECs impaired by H₂O₂. Mechanistically, PPP1R12B was found to have great potential as a target of miR-342-5p in HUVECs impaired by H₂O₂, supported by RNA-sequen

SUBMITTER: Xing X 

PROVIDER: S-EPMC7066923 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature