Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events.

ABSTRACT: Tuberculosis (TB) surveillance is scarce in most African countries, even though it is the continent with the greatest disease incidence according to the World Health Organization. Liberia is within the 30 countries with the highest TB burden, probably as a consequence of the long civil war and the recent Ebola outbreak, both crippling the health system and depreciating the TB prevention and control programmes. Due to difficulties working in the country, there is a lack of resistance surveys and bacillus characterization. Here, we use genome sequencing of Mycobacteriumtuberculosis clinical isolates to fill this gap. Our results highlight that the bacillus population structure is dominated by lineage 4 strains that harbour an outstanding genetic diversity, higher than in the re

SUBMITTER: Lopez MG 

PROVIDER: S-EPMC7067037 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature