Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses.

ABSTRACT: Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic levels caused an estimated million cases of cryptococcal meningitis per year worldwide. This species can grow in diverse environmental (trees, soil and bird excreta) and host niches (intracellular microenvironments of phagocytes and free-living in host tissues). The genetic basic for adaptation to these different conditions is not well characterized, as most experimental work has relied on a single reference strain of C. neoformans. To identify genes important for yeast infection and disease progression, we profiled the gene expression of seven C. neoformans isolates grown in five representative in vitro environmental and in vivo conditions. We characterized gene express

SUBMITTER: Yu CH 

PROVIDER: S-EPMC7067042 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature