Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis.

ABSTRACT:

Background

There is a need for improved methods for detection and risk stratification of myocarditis associated with immune checkpoint inhibitors (ICIs). Global longitudinal strain (GLS) is a sensitive marker of cardiac toxicity among patients receiving standard chemotherapy. There are no data on the use of GLS in ICI myocarditis.

Objectives

This study sought to evaluate the role of GLS and assess its association with cardiac events among patients with ICI myocarditis.

Methods

This study retrospectively compared echocardiographic GLS by speckle tracking at presentation with ICI myocarditis (cases, n = 101) to that from patients receiving an ICI who did not develop myocarditis (control subjects, n = 92). Where available, GLS was also measured pre-ICI in both groups. Ma

SUBMITTER: Awadalla M 

PROVIDER: S-EPMC7067226 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature