Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands.

ABSTRACT: Gold-based compounds are of great interest in the field of medicinal chemistry as novel therapeutic (anticancer) agents due to their peculiar reactivity and mechanisms of action with respect to organic drugs. Despite their promising pharmacological properties, the possible toxic effects of gold compounds need to be carefully evaluated in order to optimize their design and applicability. This study reports on the potential toxicity of three experimental gold-based anticancer compounds featuring lansoprazole ligands (1-3) studied in an ex vivo model, using rat precision cut kidney and liver slices (PCKS and PCLS, respectively). The results showed a different toxicity profile for the tested compounds, with the neutral complex 2 being the least toxic, even less toxic than cisplatin, followed b

SUBMITTER: Estrada-Ortiz N 

PROVIDER: S-EPMC7067241 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature