Implementation of clinically relevant and robust fMRI-based language lateralization: Choosing the laterality index calculation method.

ABSTRACT: The assessment of language lateralization has become widely used when planning neurosurgery close to language areas, due to individual specificities and potential influence of brain pathology. Functional magnetic resonance imaging (fMRI) allows non-invasive and quantitative assessment of language lateralization for presurgical planning using a laterality index (LI). However, the conventional method is limited by the dependence of the LI on the chosen activation threshold. To overcome this limitation, different threshold-independent LI calculations have been reported. The purpose of this study was to propose a simplified approach to threshold-independent LI calculation and compare it with three previously reported methods on the same cohort of subjects. Fifteen healthy subjects, who perform

SUBMITTER: Brumer I 

PROVIDER: S-EPMC7067428 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature