Alpha rhythm slowing in a modified thalamo-cortico-thalamic model related with Alzheimer's disease.

ABSTRACT: A decrease in alpha band power is defined as a hallmark of electroencephalogram (EEG) in Alzheimer's disease (AD). This study devotes to understanding the neuronal correlates of alpha rhythm slowing associated with AD from the view of neurocomputation. Firstly, a modified computational model of thalamo-cortico-thalamic (TCT) circuitry is constructed by incorporating two important biologically plausible ingredients. One is the disinhibition property between different inhibitory interneurons in the cortical module. The other is the full relay function of thalamic relay nucleus (TCR) to the cortical module. Then, by decreasing synaptic connectivity parameters to mimic the neuropathological condition of synapse loss in AD, the correlation between neuronal synaptic behavior and abnormal alpha r

SUBMITTER: Li X 

PROVIDER: S-EPMC7067465 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature