Observer Agreement and Accuracy of ¹⁸F-Sodium Fluoride PET/CT in the Diagnosis of Bone Metastases in Prostate Cancer.

ABSTRACT: Our aim was to evaluate the interobserver agreement in ¹⁸F-sodium fluoride (NaF) PET/CT for the detection of bone metastases in patients with prostate cancer (PCa). Methods: ¹⁸F-NaF PET/CT scans were retrieved from all patients who participated in 4 recent prospective trials. Two experienced observers independently evaluated the ¹⁸F-NaF PET/CT scans on a patient level using a 3-category scale (no bone metastases [M0], equivocal for bone metastases, and bone metastases present [M1]) and on a dichotomous scale (M0/M1). In patients with no more than 10 lesions, the location and number of lesions were recorded. On a patient level, the diagnostic performance was calculated using a sensitivity analysis, in which equivocal lesions were handled as M0 as well

SUBMITTER: Zacho HD 

PROVIDER: S-EPMC7067525 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature