¹⁸F-Choline PET/mpMRI for Detection of Clinically Significant Prostate Cancer: Part 1. Improved Risk Stratification for MRI-Guided Transrectal Prostate Biopsies.

ABSTRACT: A prospective single-arm clinical trial was conducted to determine whether ¹⁸F-choline PET/mpMRI can improve the specificity of multiparametric MRI (mpMRI) of the prostate for Gleason ≥ 3+4 prostate cancer. Methods: Before targeted and systematic prostate biopsy, mpMRI and ¹⁸F-choline PET/CT were performed on 56 evaluable subjects with 90 Likert score 3-5 mpMRI target lesions, using a ¹⁸F-choline target-to-background ratio of greater than 1.58 to indicate a positive ¹⁸F-choline result. Prostate biopsies were performed after registration of real-time transrectal ultrasound with T2-weighted MRI. A mixed-effects logistic regression was applied to measure the performance of mpMRI (based on prospective Likert and retrospective Prostate Imaging

SUBMITTER: Davenport MS 

PROVIDER: S-EPMC7067529 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature