Exploring Inflammatory Mediators in Fetal and Maternal Compartments During Human Parturition.

ABSTRACT:

Objective

To examine inflammatory mediators in three fetomaternal biological compartments to inform theory related to the fetal and maternal inflammatory contributions to parturition at term and preterm.

Methods

We conducted a cross-sectional study of amniotic fluid, cord blood, and maternal plasma from women with singleton pregnancies. Women had one of four conditions: term labor (n=11), term not in labor (n=13), spontaneous preterm birth with intact membranes (preterm birth; n=13), or preterm prelabor rupture of membranes (PROM; n=8). We measured two damage-associated molecular pattern markers (high-mobility group box-1 [HMGB1] and uric acid) and two acute phase response markers (interleukin [IL]-6 and C-reactive protein [CRP]) using enzyme-linked immunosorbent assay. The

SUBMITTER: Menon R 

PROVIDER: S-EPMC7067539 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature