Adipose tissue loss and lipodystrophy in xylosyltransferase II deficient mice.

ABSTRACT:

Background/objectives

The cellular and extracellular matrix (ECM) interactions that regulate adipose tissue homeostasis are incompletely understood. Proteoglycans (PGs) and their sulfated glycosaminoglycans (GAGs) provide spatial and temporal signals for ECM organization and interactions with resident cells by impacting growth factor and cytokine activity. Therefore, PGs and their GAGs could be significant to adipose tissue homeostasis. The purpose of this study was to determine the role of ECM sulfated GAGs in adipose tissue homeostasis.

Methods

Adipose tissue and metabolic homeostasis in mice deficient in xylosyltransferase 2 (Xylt2-/-) were examined by histologic analyses, gene expression analyses, whole body fat composition measurements, and glucose tolerance test. Adipo

SUBMITTER: Sivasami P 

PROVIDER: S-EPMC7067554 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature