Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts.

ABSTRACT: The distribution of complementary metabolic functions in hepatocytes along a portocentral axis is called liver zonation. Endothelial secreted Wnt ligands maintain metabolic zonation in the adult murine liver but whether those ligands are necessary to initiate zonation in the immature liver has been only partially explored. Also, numerous non-metabolic proteins display zonated expression in the adult liver but it is not entirely clear if their localization requires endothelial Wnts. Here we used a novel transgenic mouse model to compare the spatial distribution of zonated non-metabolic proteins with that of typical zonated metabolic enzymes during liver maturation and after acute injury induced by carbon tetrachloride (CCl₄). We also investigated how preventing Wnt ligand secreti

SUBMITTER: Ma R 

PROVIDER: S-EPMC7067564 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature