Neuropsychological decline up to 20 years before incident mild cognitive impairment.

ABSTRACT:

Introduction

Some Alzheimer's disease biomarker studies found amyloid changes 20 years or more in advance of expected symptoms, while cognitive changes lagged for more than a decade, but this apparent lag might reflect the sensitivities of the biomarker and cognitive assays used. How far in advance of incident amnestic mild cognitive impairment (MCI) does cognition begin to decline?

Methods

Longitudinal neuropsychological study of an apolipoprotein E e4 enriched cohort of cognitively normal individuals at entry. Linear mixed models for MCI converters (n = 65) and nonconverters (n = 719) fitted for each neuropsychological measure; annual changes compared between groups before and after linear model intersections (inflection points).

Results

34 of 35 cognitive measures

SUBMITTER: Caselli RJ 

PROVIDER: S-EPMC7067658 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature