Comparison of Al¹⁸F- and ⁶⁸Ga-labeled NOTA-PEG₄-LLP2A for PET imaging of very late antigen-4 in melanoma.

ABSTRACT: Malignant melanoma is an aggressive cancer with poor prognosis. Very late antigen-4 (VLA-4) is overexpressed in melanoma and many other tumors, making it an attractive target for developing molecular diagnostic and therapeutic agents. We compared Al¹⁸F- and ⁶⁸Ga-labeled LLP2A peptides for PET imaging of VLA-4 expression in melanoma. The peptidomimetic ligand LLP2A was modified with chelator 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA), and the resulting NOTA-PEG₄-LLP2A peptide was then radiolabeled with Al¹⁸F or ⁶⁸Ga. The two labeled peptides were assayed for in vitro and in vivo VLA-4 targeting efficiency. Good Al¹⁸F and ⁶⁸Ga radiolabeling yields were achieved, and the

SUBMITTER: Gai Y 

PROVIDER: S-EPMC7067668 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature