Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.

ABSTRACT:

Introduction

Demonstrating the "clinical meaningfulness" of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer's disease secondary prevention trials and for understanding early cognitive progression.

Methods

Cox regression analyses were used to determine whether 3-year slopes on the preclinical Alzheimer's cognitive composite predicted MCI diagnosis and global Clinical Dementia Rating>0 in 267 Aβ+ CN individuals participating in the Harvard Aging Brain Study, Australian Imaging, Biomarker and Lifestyle Study, and Alzheimer's Disease Neuroimaging Initiative.

Results

Steeper preclinical Alzheimer's cognitive composite decline over 3 years was associated with increased risk for MCI diagnosis and

SUBMITTER: Papp KV 

PROVIDER: S-EPMC7067681 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature