Age at onset of different pubertal signs in boys and girls and differential DNA methylation at age 10 and 18 years: an epigenome-wide follow-up study.

ABSTRACT:

Study question

Is the age of onset of pubertal markers related to subsequent changes in DNA methylation (DNAm)?

Summary answer

We identified 273 cytosine-phosphate-guanine (CpG) dinucleotides in girls and 67 CpGs in boys that were related to puberty and that were replicable in two other investigations.

What is known already

Previously, 457 CpGs (not gender-specific) and 347 (in girls) and 50 (in boys), respectively, were found to be associated with puberty, according to investigations of studies from Denmark (20 girls and 31 boys) and North America (30 girls and 25 boys).

Study design size duration

The study was based on a birth cohort of 1456 participants born in 1989/90, with follow-up at age 10 and 18 years.

Participants/materials setting methods

The

SUBMITTER: Chen S 

PROVIDER: S-EPMC7067683 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature