The influence of time to adrenaline administration in the Paramedic 2 randomised controlled trial.

ABSTRACT:

Purpose

To examine the time to drug administration in patients with a witnessed cardiac arrest enrolled in the Pre-Hospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration in Cardiac Arrest (PARAMEDIC2) randomised controlled trial.

Methods

The PARAMEDIC2 trial was undertaken across 5 NHS ambulance services in England and Wales with randomisation between December 2014 and October 2017. Patients with an out-of-hospital cardiac arrest who were unresponsive to initial resuscitation attempts were randomly assigned to 1 mg intravenous adrenaline or matching placebo according to treatment packs that were identical apart from treatment number. Participants and study staff were masked to treatment allocation.

Results

8016 patients were

SUBMITTER: Perkins GD 

PROVIDER: S-EPMC7067734 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature