Diabetes Minimally Mediated the Association Between PM_2.5 Air Pollution and Kidney Outcomes.

ABSTRACT: Epidemiologic observations suggest that exposure to ambient fine particulate matter (PM_2.5) is associated with increased risk of chronic kidney disease (CKD) and diabetes, a causal driver of CKD. We evaluated whether diabetes mediates the association between PM_2.5 and CKD. A cohort of 2,444,157 United States veterans were followed over a median 8.5 years. Environmental Protection Agency data provided PM_2.5 exposure levels_. Regression models assessed associations and their proportion mediated. A 10 µg/m³ increase in PM_2.5 was associated with increased odds of having a diabetes diagnosis (odds ratio: 1.18, 95% CI: 1.06-1.32), use of diabetes medication (1.22, 1.07-1.39), and increased risk of incident eGFR <60 ml/min/1.73 m

SUBMITTER: Bowe B 

PROVIDER: S-EPMC7067761 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature