Observer variability in the assessment of renal ¹⁸F-FDG uptake in kidney transplant recipients.

ABSTRACT: ¹⁸F-FDG PET/CT imaging may help non-invasively disprove the diagnosis of acute kidney allograft rejection (AR) in kidney transplant recipients (KTR). The present study aims at evaluating the repeatability and reproducibility of the quantification of renal ¹⁸F-FDG uptake in KTR. We prospectively performed ¹⁸F-FDG PET/CT in 95 adult KTR who underwent surveillance transplant biopsy between 3 to 6 months post transplantation. Images were obtained 180 minutes after injecting 3 MBq ¹⁸F-FDG per kg body weight. Mean standard uptake value (SUV_mean) of kidney cortex was independently measured by 2 experienced observers in 4 volumes of interest (VOI) distributed in the upper (n = 2) and lower (n = 2) poles. The first observer repeated SUV assessm

SUBMITTER: Jadoul A 

PROVIDER: S-EPMC7067780 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature