Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis.

ABSTRACT: Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs), promoting inflammation and coagulation. Patients with sepsis have increased levels of extracellular histones, which have been shown to correlate with poor prognosis and the development of sepsis-related sequelae, such as end-organ damage. Until now, neutrophils were assumed to be the primary source of circulating histones during sepsis. In this paper, we show that megakaryocytes contain extranuclear histones and transfer histones to their platelet progeny. Upon examination of isolated platelets from patients with sepsis, we identified that pat

SUBMITTER: Frydman GH 

PROVIDER: S-EPMC7067782 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature