Jointly modelling longitudinally measured urinary human chorionic gonadotrophin and early pregnancy outcomes.

ABSTRACT: Human chorionic gonadotrophin (hCG) is largely used to confirm pregnancy. Yet evidence shows that longitudinal hCG profiles are distinguishable between healthy and failing pregnancies. We retrospectively fitted a joint longitudinal-survival model to data from 127 (85 healthy and 42 failing pregnancies) US women, aged 18-45, who were attempting to conceive, to quantify the association between longitudinally measured urinary hCG and early miscarriage. Using subject-specific predictions, obtained uniquely from the joint model, we investigated the plausibility of adaptively monitoring early pregnancy outcomes based on updating hCG measurements. Volunteers collected daily early morning urine samples for their menstrual cycle and up to 28 days post day of missed period. The longitudinal submodel

SUBMITTER: Ashra NB 

PROVIDER: S-EPMC7067806 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature