Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.

ABSTRACT: Biological aging results in changes in an organism that accumulate over age in a complex fashion across different regulatory systems, and their cumulative effect manifests in increased physiological dysregulation (PD) and declining robustness and resilience that increase risks of health disorders and death. Several composite measures involving multiple biomarkers that capture complex effects of aging have been proposed. We applied one such approach, the Mahalanobis distance (D_M), to baseline measurements of various biomarkers (inflammation, hematological, diabetes-associated, lipids, endocrine, renal) in 3,279 participants from the Long Life Family Study (LLFS) with complete biomarker data. We used D_M to estimate the level of PD by summarizing information about multip

SUBMITTER: Arbeev KG 

PROVIDER: S-EPMC7067825 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature