Sustained Improvements in Markers of Liver Disease Severity After Hepatitis C Treatment.

ABSTRACT:

Background & aims

Although serological markers of disease severity improve after hepatitis C virus (HCV) treatment, it is unclear if all patients experience sustained improvement. We aim to evaluate longitudinal changes in aspartate (AST), alanine (ALT) aminotransferase, platelet count (PLT), and fibrosis-4 (FIB-4) after HCV treatment.

Methods

All adult chronic HCV patients who received antiviral therapy from January 2011 to February 2017 at four large urban hospital systems were evaluated to assess changes in AST, ALT, PLT, and FIB-4 from pre-treatment to post-treatment annually up to 4 years after HCV therapy. Comparisons used Student's t-test and analysis of variance, and were stratified by sex, race, ethnicity, age, body mass index (BMI), and diabetes mellitus.

SUBMITTER: Wong RJ 

PROVIDER: S-EPMC7068013 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature