High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo- and autoimmunity.

ABSTRACT: Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse functions, and the composition of iNKT cell subsets can alter disease outcomes. In contrast, far less is known about how heterogeneity in human iNKT cells relates to disease. To address this, we used a high-dimensional, data-driven approach to devise a framework for parsing human iNKT heterogeneity. Our data revealed novel and previously described iNKT cell phenotypes with distinct functions. In particular, we found 2 phenotypes of interest: (1) a population with T helper 1 function that was increased with iNKT activation characterized by HLA-II+CD161- expre

SUBMITTER: Erkers T 

PROVIDER: S-EPMC7068034 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature