Prenatal Ambient Particulate Matter Exposure and Longitudinal Weight Growth Trajectories in Early Childhood.

ABSTRACT: Air pollution exposure during pregnancy has been associated with impaired fetal growth and postnatal weight gain, but few studies have examined the effect on weight growth trajectories. We examine the association between validated 1 km² resolution particulate matter (PM_2.5) concentrations, averaged over pregnancy, and sex-specific growth trajectories from birth to age six of participants in the Boston-based Children's HealthWatch cohort (4797 participants, 84,283 measures). We compared weight trajectories, predicted using polynomial splines in mixed models, between prenatal PM_2.5 above or below the median (9.5 µg/m³), and examined birth weight as an effect modifier. Females exposed to average prenatal PM_2.5 ≥ 9.5 µg/m³ had h

SUBMITTER: Rosofsky AS 

PROVIDER: S-EPMC7068568 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature