Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.

ABSTRACT: Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2⁺ lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation

SUBMITTER: Jaitin DA 

PROVIDER: S-EPMC7068689 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature